منابع مشابه
Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class.
A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with leve...
متن کامل5368 Tubulin Polymerization in Dimethyl Sulfoxide
The self-assembly of tubulin devoid of microtubuleassociated proteins (MAPs) has been studied using a MES buffer containing dimethyl sulfoxide (MezSO). Between 6% and 12% v/v MeZSO, the tubulin forms polymers which resemble microtubules in their morphology and chemical properties. These MezSO microtubules, like normal microtubules, require GTP for assembly and are sensitive to cold, calcium ion...
متن کاملHeterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization.
Tau is an intrinsically disordered protein with a central role in the pathology of a number of neurodegenerative diseases. Tau normally functions to stabilize neuronal microtubules, although the mechanism underlying this function is not well understood. Of note is that the interaction between tau and soluble tubulin, which has implications both in understanding tau function as well as its role ...
متن کاملTubulin polymerization promoting protein 1 (TPPP1)
The eukaryotic cell cycle relies heavily on the mechanical forces vested by the dynamic rearrangement of the microtubule (MT) network. Tubulin Polymerization promoting Protein 1 (TPPP1) alters MT dynamics by driving MT polymerization as well as stabilization, via increasing MT acetylation. It increases MT rigidity, which results in reduced cell proliferation through downregulation of G1/S-phase...
متن کاملNeurofilaments bind tubulin and modulate its polymerization.
Neurofilaments assemble from three intermediate-filament proteins, contribute to the radial growth of axons, and are exceptionally stable. Microtubules are dynamic structures that assemble from tubulin dimers to support intracellular transport of molecules and organelles. We show here that neurofilaments, and other intermediate-filament proteins, contain motifs in their N-terminal domains that ...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2012
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-012-0886-2